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5th Healthy Ageing Research Centre (HARC) Workshop DISREGULATION OF CELL-MATRIX INTERACTIONS IN AGE-RELATED DISEASES
date of event: November 5, 2015
remaining places: 24
deadline of the registration: 2015-11-03

registration is closed
Registration opens: 2015-09-01

Workshops

5th Healthy Ageing Research Centre (HARC) Workshop

DISREGULATION OF CELL-MATRIX INTERACTIONS
IN AGE-RELATED DISEASES

November 5th and 6th, 2015 Łódź, Poland

Venue: Western Hall; Medical University of Łódź

Pomorska 251, Łódź

Healthy Ageing Research Centre and Medical University of Łódź would like to invite you to participate in the 5th HARC Workshop “Disregulation of cell-matrix interactions in age-related diseases”. The workshop will take place at Medical University of Lodz, on November 5th – 6th, 2015. The 5th HARC Workshop will be tribute to Prof. Czeslaw S. Cierniewski who passed away on October 24th, 2013. The special emphasis will be put on molecular aspects of cell-matrix interactions of endothelial cells in ageing. Ten eminent researchers coming from the most famous academic institutions all over the world will give lectures. They will be accompanied by one or two students who will give short oral communications based on their research results.

The workshop is dedicated to all professionals – researchers interested in different medical aspects of ageing, physicians and other health service providers.

If you have any questions or need more information about HARC, please don’t hesitate to contact us harc@umed.pl or have a look at our website www.harc.umed.pl, where you can also find a registration form for 5th HARC Workshop.

 

Day 1 Thursday, November 5th, 2015

 

9:00 Welcome

 

SESSION I

TARGETING OF VASCULATURE IN CANCER AND AGE RELATED DISEASES

9:15 The role of thrombospondin-4 (TSP-4) in ageing and cardiovascular diseases – Prof. Edward Plow (USA)

9:45 The Kindlin proteins as potential targets of anti-angiogenic therapies – dr Elzbieta Pluskota (USA)

10:15 Discussion

10:25 Coffee break

11:00 Vascular cell signaling in healthy and pathological tissues: effect of ageing – dr Agnieszka Loboda (Poland)

11:30 To be still young  - role of heme oxygenase-1 in hematopoietic stem cells – Prof. Alicja Jozkowicz (Poland)

12:00 Spheroid-plug model – novel approach in anticancer drug screening – dr Monika Zukowska (Poland)

12:20 Novel TRAIL-based fusion molecule for cancer treatment – dr Anna Grochot – Przeczek (Poland)

12:40 Discussion

12:50 Lunch

14:00 Conserved collagens in non-melanoma skin cancer – Prof. Ritva Heljasvaara (Finland)

14:30 CAF-derived integrin alpha11 in cutaneous squamous cell carcinoma - Guillermo Martinez-Nieto (Finland)

14:50 Collagen XVIII in breast cancer - a regulator of growth factor receptor-integrin crosstalk and a therapeutic target? - Raman Devarajan (Finland)

15:10 Discussion

15:20 Collagen XIII in bone homeostasis – dr Jarkko Koivunen (Finland)

15:50 Discussion

16:00 Closing remarks

 

Day 2 Friday, November 6th, 2015

 

SESSION II

CELL-MATRIX INTERACTIONS IN AGEING

9:00 Role of integrin alpha11 in wound healing – Prof. Donald Gullberg (Norway)

9:30 In vitro methods to study the fibrogenic phenotype in connective tissue cells – dr Cedric Zeltz (Norway)

10:00 Elucidating the molecular details of integrin alpha11 function – Pugazendhi Erusappan (Norway)

10:20 Discussion

10:30 Coffee break

11:10 Matrix metalloproteinase-2 cleavage of the β1 integrin ectodomain facilitates colon cancer cell motility – dr Jakub Kryczka (Poland)

11:30 Discussion

11:40 Matrikins-matricryptin exacerbates the inflammatory response in bullous pemphigoid – Prof. Frank Antonicelli (France)

12:10 Development of Infrared and Raman vibrational spectro-imaging for the characterization of glycosaminoglycans in cancer during aging – Prof. Stephane Brezillon (France)

12:40 Discussion

12:50 Lunch

 

SESSION III

MOLECULAR THERAPY IN AGEING

14:00 Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke – Prof. Paul Declerc (Belgium)

14:30 Elucidation of the molecular mechanisms of two nanobodies that inhibit TAFI activation and TAFIa activity – dr Xiaohua ZHOU (Belgium)

14:50 Discussion

15:00 Emerging new approaches based on nucleic acids chemistry – Prof. Lucyna Wozniak (Poland)

15:30 Synthetic nucleic acids as a tools in molecular therapy – dr Malgorzata Bukowiecka – Matusiak (Poland)

15:50 Discussion

16:00 Closing remarks




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