Date: March 10th—11th, 2016
Venue: Didactic Centre of the Medical University of Lodz,
ul. Pomorska 251, Łódź
Healthy Ageing Research Centre, Medical University of Łódź and Institute of Medical Biology PAS would like to invite you to participate in the 8th HARC Workshop “Nucleic Acids in Medicine: perspectives for new diagnostic and therapeutic tools”.
The workshop will take place at Medical University of Lodz, on March 10th – 11th, 2016. The aim of this workshop is to present recent advances and nucleic acids applications in different fields of biomedical research. The major areas covered in this workshop are following:
1. Structure and reactivity of nucleic acids
2. Catalytic nucleic acids
3. Synthesis and properties of nucleic acids analogs
4. Diagnostic tools
5. Nucleic acids as potential therapeutics
Registration: Participation in the Workshop is free of charge. Registration is available on the website www.harc.umed.pl since January, 26th, 2016.
Due to limited number of seats, first come, first served. Confirmation of the participation will be send via email.
Please note that there is an opportunity to present original research within topic “Current research reports. Presentation of scientific research area”, that will be presented during the poster session (after approval of the Scientific Committee). Abstracts (max. 300 words) should be sent by email: email@example.com by March 1st, 2016.
Information on the researcher activity (Times New Roman, 12) - 2 sentences, max. 50 words [for networking purposes].
If you have any questions or need more information about HARC, please don’t hesitate to contact us firstname.lastname@example.org or have a look at our website www.harc.umed.pl, where you can also find
a registration form for 8th HARC Workshop.
Prof. Lucyna Woźniak PhD
Vice-Rector for Research
Department of Structural Biology, Head
Medical University of Lodz
Prof. Zbigniew J. Leśnikowski, Ph.D.
Head, Laboratory of Molecular Virology
and Biological Chemistry
Institute of Medical Biology PAS
March 10th, 2016 (Thursday)
9.00-9.15 Opening remarks
Chairperson: Prof. Lucyna Woźniak
9.15-10.00 Keynote lecture: Some recent advances in chemical synthesis of nucleic acids and their components.
Wojciech Markiewicz, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
10.00-10.20 Modification with boron clusters – New forays into therapeutic nucleic acids design.
Zbigniew Leśnikowski, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
10.20-10.40 Boron clusters as redox labels for electrochemical detection of DNA-probes.
Agnieszka Olejniczak, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
10.40- 11.10 DNA tools to select anti-bacterial glycoclusters.
Francois Morvan, Institut des Biomolecules Max Mousseron, Montpellier, France
11.10 -11.30 Coffee break
Chairperson: Prof. Zbigniew Leśnikowski
11.30-12.00 tRNA damage in oxidative stress: desulfuration of wobble 2-thiouridines.
Barbara Nawrot, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
12.00-12.30 Proangiogenic activity of nucleoside 5'-O-phosphorothioate analogues under hyperglycaemic conditions
Maria Koziołkiewicz, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Poland
12.30-13.00 From Energy transfer to DNA damage.
Bolesław Karwowski, Faculty of Pharmacy, Medical University of Lodz, Poland
13.00-14.00 Lunch break and poster session
Chairperson: Prof. Marcus Duechler
14.00-14.30 Aberrant Notch pathway signaling in cancer.
Andrzej Bednarek, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Poland
14.30-15.00 Understanding tolerance to protein mistranslation and aggregation.
Manuel Santos, Medical Sciences Department, Institute of Biomedicine - iBiMED, University of Aveiro, Portugal
15.00-15.15 Identification of conserved tRNA derived fragments in zebrafish reveals their potential as gene expression modulators and disease biomarkers
Ana Soares, Medical Sciences Department, Institute of Biomedicine - iBiMED, University of Aveiro, Portugal
15.15-15.45 In vitro and in vivo metabolomic analysis of arginine deprivation therapy in malignant pleural mesothelioma.
Peter Szlosarek, Centre for Molecular Oncology, Barts Cancer Institute, London, United Kingdom
15.45-16.15 Novel nucleotide analogues that overcome the key cancer drug resistance limiting patient survival.
Essam A. Ghazaly, Centre for Haemato-Oncology, Barts Cancer Institute, London, United Kingdom
16.15-16.30 Open discussion
March 11th, 2016 (Friday)
Chairperson: Prof. Manuel Santos
9.45-10.15 180° Turn - hompurine ([All-RP-PS]-DNA oligomers form stable parallel complexes with Hoogsteen paired nucleic acids.
Piotr Guga, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
10.15-10.30 Thermodynamic properties of complexes formed by stereodefined PS-oligos containing LNA units with complementary DNA templates.
Katarzyna Jastrzębska, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
10.30-11.00 Comprehensive protection via thermolabile groups for bioconjugates synthesis.
Jolanta Brzezińska, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
11.00 -11.30 Coffee break
Chairperson: Prof. Piotr Guga
11.30-12.00 RNA nano-objects as programmable therapeutics.
Arkadiusz Chworoś, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
12.00-12.15 RNA trimer as a gene regulating nano-particle in a model GFP system.
Dominika Jędrzejczyk, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
12.15-12.45 Anti-aging properties of N4-furfurylcytosine.
Eliza Wyszko, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
12.45-13.15 Exosome-transported miRNAs may contribute to cancer immunosuppression.
Marcus Duechler, Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Lodz, Poland
13.15-13.45 Open discussion and concluding remarks
13.45-14.30 Lunch break