The 7th Workshop "Molecular Pathology of the Nervous System", organized by HARC in collaboration with the Department of Molecular Pathology and Neuropathology of the Medical University of Lodz took place on February 25th-26th 2016 in the Didactic Centre of the Medical University of Lodz. The main aim of this workshop was to present the to the Polish and European audience the modern views on the molecular pathogenesis of the neurodegenerative diseases of the nervous system. The workshop guests included experts from the United Kingdom, Germany, Switzerland, Austria and Italy.
The first day of the meeting started with Professor Robert Will’s (University of Edinburgh, United Kingdom) lecture on the patterns, causes and epidemiology of Creutzfeldt-Jakob disease and Bovine Spongiform Encephalopathy in the European countries. This presentation was supplemented with lectures presented by Professor James Ironside (University of Edinburgh, United Kingdom) and Professor Herbert Budka (University Hospital Zurich, Switzerland) updating our knowledge on neurodegenerative and prion diseases. Professor Marcus Glatzel (University Medical Center Hamburg-Eppendorf, Germany) summarized his studies on the role of metalloproteinase ADAM10 in production of neurotoxic amyloid β peptide in Alzheimer’s disease. The mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity, using synthetic prions were discussed by Professor Giuseppe Legname (Scuola Internazionale Superiore di Studi Avanzati, Italy). At the end of the first day of the meeting Professor Beata Sikorska (Medical University of Lodz) presented the prion-like diseases and explained how prionoids differ from “real” prions. The first day of the meeting also included the poster session for young scientists presenting results of their research related to neurodegenerative diseases.
The second day of the meeting started from Professor Richard Knight (University of Edinburgh, United Kingdom) presenting the detailed clinical features and diagnostic methods aimed at detecting Creutzfeldt-Jakob disease and its variants. Analysis of the cerebrospinal fluid used for diagnostics of human CJD and its application as a model to study neurodegenerative disorders in humans were reported upon the own research by Professor Inga Zerr (Georg-August University, Germany). Then, the characteristic features of diseases caused by disorders of the tau peptide (tauopathies) were discussed by Professor Gabor Kovacs (Medical University of Vienna, Austria). Professor Pawel Liberski (Medical University of Lodz) in his rich in photographs lecture presented kuru disease and discussed the history, epidemiology and clinical features of this neurodegenerative disease. Finally, both days of the meeting were summarized during the discussion chaired by Professor Heino Diringer (Berlin, Germany).