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Molecular basis of ageing
August 27, 2013

(Leader: Prof. Jolanta Niewiarowska, Prof. Czesław Cierniewski (†))

Several molecular mechanism are involved in cell senescence. This groups will focus on two selected issues:

  1. different aspects of molecular mechanisms regulating adhesion and migration of endothelial cells during angiogenesis induced by different agent and
  2. oxidativestress-induced DNA damage and dysfunctional telomeres in the pathogenesis of atherosclerosis.

We are particularly interested in the role of integrin receptors and plasminogen activator inhibitor type 1 (PAI-1) in cancer cells, searching for mechanisms increasing their invasiveness.

The second area of molecular research will focus on DNA interactions with other biomolecules, elaboration of molecular mechanisms of oxidative stress, causing atherosclerosis, an intrinsically agerelated disease. Premature atherosclerosis is a feature of several human diseases that are known to be defective in DNA repair pathways and characterized by predisposition to early onset of age-related diseases.

  1. Department of Biochemical Sciences, Faculty of Medicine and Surgery University of Florence, Italy - Professor Paola Chiarugi
  2. Centre National de la Recherche Scientifique et Université de Reims Champagne-Ardenne (CNRS UMR 6237), Reims, France - Professor François-Xavier MAQUART
  3. The National Italian Agency for New Technology, Energy and Sustainable Economy, Rome. Italy - Professor Laura Teodori
  4. Consilgio Nazionale delle Ricerche, ISOF - CNR Area della Ricerca di Bologna; Bologna – Italy - Dr. Chryssostomos Chatgilialoglu,
  5. Department of Bioorganic Chemistry, Biomedical Centre, University of Uppsala, Uppsala, Sweden - Professor Jyotti Chattopadhyaya
  6. Labolatory of Pharmaceutical Biology, Catholic University of Leuven, Belgium – prof. Paul Declerc
  7. ISOF – CNF, Bologna, Italy – dr Carla Ferreri

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